Applied Mathematics and Numerical Analysis Seminar  RSS

Planned

11/04/2024, 15:00 — 16:00 — Room P3.10, Mathematics Building Instituto Superior Técnicohttps://tecnico.ulisboa.pt
Alberto Girelli, Department of Mathematics and Physics Università Cattolica del Sacro Cuore Brescia, Italy

Multiscale Modelling of Fluid Flow in a Lymph Node

Lymph nodes (LNs) are organs scattered throughout the lymphatic system which play a vital role in our immune response by breaking down bacteria, viruses, and waste; the interstitial fluid, called lymph once inside the lymphatic system, is of fundamental importance in this process as it transports these substances inside the lymph node. The main mechanical features of the lymph node include the presence of a porous bulk region (lymphoid compartment, LC), surrounded by a thin layer (subcapsular sinus, SCS) where the fluid can flow freely.

These nodes are vital for filtering and processing lymph, which contains immune cells, antigens, and other molecules. Understanding the fluid dynamics within lymph nodes is essential for elucidating immune mechanisms and developing therapies for lymphatic disorders. Despite its significance, few models in the literature attempt to describe lymph behavior from a mechanical perspective.

In this talk, we will introduce a mathematical model, derived using the asymptotic homogenization technique, to describe fluid flow within a lymph node, considering its multiscale nature. We will discuss how this model can elucidate flow patterns, pressure distribution, and shear stress within the node.

Email announcements subscription

This seminar series has an active subscriber list. It is used by the seminar organizer to publicize events. To request or cancel membership add your name and email below. Depending on your address being on the list or not you will be able to unsubscribe or subscribe.

Data submission

CEMAT logo